Double-stranded RNA induction asa potential dynamic biomarkerfor DNA-demethylating agents

Hypomethylating agents (HMAs), such as azacitidine and decitabine, induce cancer cell death by demethylating DNAs to promote the expression of tumor-suppressor genes. HMAs also reactivate the transcription of endogenous double-stranded RNAs (dsRNAs) that trigger the innate immune response and subseq...

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Bibliographic Details

Published in:	Molecular Therapy: Nucleic Acids
Main Authors:	Minjeong Kang, Raisa Kharbash, Ja Min Byun, Jaemin Jeon, Ahsan Ausaf Ali, Doyeong Ku, Jimin Yoon, Yongsuk Ku, Jooyeon Sohn, Seung-Jae V. Lee, Dong-Yeop Shin, Youngil Koh, Sung-Soo Yoon, Junshik Hong, Yoosik Kim
Format:	Article
Language:	English
Published:	Elsevier 2022-09-01
Subjects:	MT: Noncoding RNAs hypomethylating agents spiropyran double-stranded RNAs dynamic biomarker PKR
Online Access:	http://www.sciencedirect.com/science/article/pii/S2162253122001834