Functional development of a V3/glycan-specific broadly neutralizing antibody isolated from a case of HIV superinfection

Stimulating broadly neutralizing antibodies (bnAbs) directly from germline remains a barrier for HIV vaccines. HIV superinfection elicits bnAbs more frequently than single infection, providing clues of how to elicit such responses. We used longitudinal antibody sequencing and structural studies to c...

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出版年:	eLife
主要な著者:	Mackenzie M Shipley, Vidya Mangala Prasad, Laura E Doepker, Adam Dingens, Duncan K Ralph, Elias Harkins, Amrit Dhar, Dana Arenz, Vrasha Chohan, Haidyn Weight, Kishor Mandaliya, Jesse D Bloom, Frederick A Matsen IV, Kelly K Lee, Julie M Overbaugh
フォーマット:	論文
言語:	英語
出版事項:	eLife Sciences Publications Ltd 2021-07-01
主題:	HIV broadly neutralizing antibody V3 superinfection cryo-EM lineage development
オンライン･アクセス:	https://elifesciences.org/articles/68110