Combining genetic proxies of drug targets and time-to-event analyses from longitudinal observational data to identify target patient populations

Abstract Background Human genetics is an important tool for identifying genes as potential drug targets, and the extensive genetic study of cardiovascular disease provides an opportunity to leverage genetics to match specific patient populations to specific drug targets to improve prioritization of...

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Bibliographic Details

Published in:	BMC Cardiovascular Disorders
Main Authors:	Luke Zhang, Prachi Kulkarni, Farshad Farshidfar, Whit Tingley, Tim Hoey, Whedy Wang, James R. Priest, Sylwia M. Figarska
Format:	Article
Language:	English
Published:	BMC 2025-05-01
Subjects:	Drug target discovery Patients selection in silico trials Cardiovascular outcomes
Online Access:	https://doi.org/10.1186/s12872-025-04753-1