IS4‐FAM, a fluorescent tool to study CXCR4 affinity and competitive antagonism in native cancer cells

Abstract The ability to accurately measure drug‐target interaction is critical for the discovery of new therapeutics. Classical pharmacological bioassays such as radioligand or fluorescent ligand binding assays can define the affinity or Kd of a ligand for a receptor with the lower the Kd, the stron...

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Bibliographic Details

Published in:	Pharmacology Research & Perspectives
Main Authors:	Isabel Hamshaw, Marco M. D. Cominetti, Princess Nana‐Akyin, Ernie Ho Yee Ho, Mark Searcey, Anja Mueller
Format:	Article
Language:	English
Published:	Wiley 2024-10-01
Subjects:	antagonist chemokine receptor CXCL12 CXCR4
Online Access:	https://doi.org/10.1002/prp2.70003