CircRNA hsa_circ_0004781 promoted cell proliferation by acting as a sponge for miR-9-5p and miR-338-3p and upregulating KLF5 and ADAM17 expression in pancreatic ductal adenocarcinoma

Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive types of solid tumor, and novel strategies must be developed for treating it. Previous studies predominantly utilized circular RNA (circRNA) expression plasmids incorporating Alu elements to facilitate the indi...

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Bibliographic Details

Published in:	Cancer Cell International
Main Authors:	Kun-Lin Lee, Jun-Jen Liu, Wei-Jan Huang, Ching-Sheng Hung, Yu-Chih Liang
Format:	Article
Language:	English
Published:	BMC 2025-02-01
Subjects:	Real circRNA Hsa_circ_0004781 miR-9-5p miR-338-3p KLF5 ADAM17
Online Access:	https://doi.org/10.1186/s12935-025-03687-0