A Multilevel Bayesian Approach to Improve Effect Size Estimation in Regression Modeling of Metabolomics Data Utilizing Imputation with Uncertainty

To ensure scientific reproducibility of metabolomics data, alternative statistical methods are needed. A paradigm shift away from the <i>p</i>-value toward an embracement of uncertainty and interval estimation of a metabolite’s true effect size may lead to improved study design and great...

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Bibliographic Details

Published in:	Metabolites
Main Authors:	Christopher E. Gillies, Theodore S. Jennaro, Michael A. Puskarich, Ruchi Sharma, Kevin R. Ward, Xudong Fan, Alan E. Jones, Kathleen A. Stringer
Format:	Article
Language:	English
Published:	MDPI AG 2020-08-01
Subjects:	hierarchical modeling nuclear magnetic resonance spectroscopy Bayesian statistics missing values imputation multiple test corrections
Online Access:	https://www.mdpi.com/2218-1989/10/8/319