LARGE DELETIONS AND SMALL INSERTIONS AND DELETIONS IN THE FACTOR VIII GENE PREDICT FAILURE TO IMMUNE TOLERANCE INDUCTION IN PEOPLE WITH SEVERE HEMOPHILIA A AND HIGH-RESPONDING INHIBITORS
Introduction: Alloantibodies against factor VIII (FVIII; inhibitors) are the main complication of hemophilia A. Immune tolerance induction (ITI) eradicates inhibitors in about 70% of people with hemophilia A. Few studies have evaluated the role of FVIII gene (F8) variants on ITI outcome. Material an...
| Published in: | Hematology, Transfusion and Cell Therapy |
|---|---|
| Main Authors: | , , , , , , , , |
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-10-01
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2531137924013105 |