Phage resistance formation and fitness costs of hypervirulent Klebsiella pneumoniae mediated by K2 capsule-specific phage and the corresponding mechanisms

IntroductionPhage is promising for the treatment of hypervirulent Klebsiella pneumoniae (hvKP) infections. Although phage resistance seems inevitable, we found that there still was optimization space in phage therapy for hvKP infection.MethodsThe clinical isolate K. pneumoniae FK1979 was used to rec...

وصف كامل

التفاصيل البيبلوغرافية

الحاوية / القاعدة:	Frontiers in Microbiology
المؤلفون الرئيسيون:	Miran Tang, Zeyu Huang, Xiaodong Zhang, Jingchun Kong, Beibei Zhou, Yijia Han, Yi Zhang, Lijiang Chen, Tieli Zhou
التنسيق:	مقال
اللغة:	الإنجليزية
منشور في:	Frontiers Media S.A. 2023-07-01
الموضوعات:	bacteriophage phage resistance hypervirulent Klebsiella pneumoniae capsular polysaccharides lipopolysaccharides polysaccharide depolymerase
الوصول للمادة أونلاين:	https://www.frontiersin.org/articles/10.3389/fmicb.2023.1156292/full