Quality by Design Optimization of Cold Sonochemical Synthesis of Zidovudine-Lamivudine Nanosuspensions

Lamivudine (3TC) and zidovudine (AZT) are antiviral agents used to manage HIV/AIDS infection. The compounds require frequent dosing, exhibit unpredictable bioavailability and a side effect profile that includes hepato- and haema-toxicity. A novel pseudo one-solvent bottom-up approach and Design of E...

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Bibliographic Details

Published in:	Pharmaceutics
Main Authors:	Bwalya A. Witika, Vincent J. Smith, Roderick B. Walker
Format:	Article
Language:	English
Published:	MDPI AG 2020-04-01
Subjects:	nano co-crystals design of experiments Quality by Design crystal engineering sonochemistry HIV/AIDS
Online Access:	https://www.mdpi.com/1999-4923/12/4/367