Modeling Synucleinopathy Using hESC-Derived Cerebral Organoids

Animal and cellular models harboring <i>SNCA</i> gene mutations have been instrumental in synucleinopathy, but faithful human brain models remain limited. Here, we report the development of a human cerebral organoid (CO) model of synucleinopathy carrying the Ala53Thr mutation in <i>...

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書誌詳細

出版年:	Cells
主要な著者:	So Jin Kim, Won Hee Jung, Mu Seog Choe, Ye Seong Jeon, Min Young Lee
フォーマット:	論文
言語:	英語
出版事項:	MDPI AG 2025-09-01
主題:	cerebral organoid human pluripotent stem cells synucleinopathy disease modeling drug testing
オンライン･アクセス:	https://www.mdpi.com/2073-4409/14/18/1436