Modeling Synucleinopathy Using hESC-Derived Cerebral Organoids

Animal and cellular models harboring <i>SNCA</i> gene mutations have been instrumental in synucleinopathy, but faithful human brain models remain limited. Here, we report the development of a human cerebral organoid (CO) model of synucleinopathy carrying the Ala53Thr mutation in <i>...

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Bibliographic Details
Published in:Cells
Main Authors: So Jin Kim, Won Hee Jung, Mu Seog Choe, Ye Seong Jeon, Min Young Lee
Format: Article
Language:English
Published: MDPI AG 2025-09-01
Subjects:
cerebral organoid
human pluripotent stem cells
synucleinopathy
disease modeling
drug testing
Online Access:https://www.mdpi.com/2073-4409/14/18/1436

Internet

https://www.mdpi.com/2073-4409/14/18/1436

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