O-GlcNAcylation controls pro-fibrotic transcriptional regulatory signaling in myofibroblasts

Abstract Tissue injury causes activation of mesenchymal lineage cells into wound-repairing myofibroblasts (MFs), whose uncontrolled activity ultimately leads to fibrosis. Although this process is triggered by deep metabolic and transcriptional reprogramming, functional links between these two key ev...

Full description

Bibliographic Details

Published in:	Cell Death and Disease
Main Authors:	Ninon Very, Clémence Boulet, Céline Gheeraert, Alexandre Berthier, Manuel Johanns, Mohamed Bou Saleh, Loïc Guille, Fabrice Bray, Jean-Marc Strub, Marie Bobowski-Gerard, Francesco P. Zummo, Emmanuelle Vallez, Olivier Molendi-Coste, Eloise Woitrain, Sarah Cianférani, David Montaigne, Line Carolle Ntandja-Wandji, Laurent Dubuquoy, Julie Dubois-Chevalier, Bart Staels, Philippe Lefebvre, Jérôme Eeckhoute
Format:	Article
Language:	English
Published:	Nature Publishing Group 2024-06-01
Online Access:	https://doi.org/10.1038/s41419-024-06773-9