High-resolution acoustic ejection mass spectrometry for high-throughput library screening

An approach is described for high-throughput quality assessment of drug candidate libraries using high-resolution acoustic ejection mass spectrometry (AEMS). Sample introduction from 1536-well plates is demonstrated for this application using 2.5 nL acoustically dispensed sample droplets into an Ope...

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Bibliographic Details

Published in:	SLAS Technology
Main Authors:	Nate Hoxie, David R. Calabrese, Zina Itkin, Glenn Gomba, Min Shen, Meghav Verma, John S. Janiszewski, Jonathan H. Shrimp, Kelli M. Wilson, Sam Michael, Matthew D. Hall, Lyle Burton, Tom Covey, Chang Liu
Format:	Article
Language:	English
Published:	Elsevier 2024-12-01
Subjects:	High-throughput mass spectrometry HTMS Acoustic droplet ejection AEMS AE-MS HT-MS
Online Access:	http://www.sciencedirect.com/science/article/pii/S2472630324000815