Enhancing mRNA translation efficiency with discriminative and generative artificial intelligence by optimizing 5′ UTR sequences

Summary: The mRNA-based therapeutics, notably mRNA vaccines, represent a new era of powerful tools to combat various diseases. However, the relatively low translation efficiency of exogenous mRNA often limits its wide application. Here, we propose a computational framework called UTailoR (UTR tailor...

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Bibliographic Details

Published in:	iScience
Main Authors:	Yu Liu, Chunmei Cui, Limei Liu, Qinghua Cui
Format:	Article
Language:	English
Published:	Elsevier 2025-10-01
Subjects:	Biochemistry artificial intelligence
Online Access:	http://www.sciencedirect.com/science/article/pii/S258900422501805X