Bexarotene ameliorated the pulmonary inflammation and M1 polarization of alveolar macrophages induced by cigarette smoke via PPARγ/HO-1

Abstract Background Alveolar macrophages (AMs) modulate pulmonary inflammation in chronic obstructive pulmonary disease (COPD), contributing to its progression. The PPARγ/RXRα heterodimer influences AM polarization induced by cigarette smoke (CS). Although PPARγ agonists suppress CS-induced M1 macro...

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出版年:	Respiratory Research
主要な著者:	Haoshen Feng, Zhe Li, Rui Zheng
フォーマット:	論文
言語:	英語
出版事項:	BMC 2024-12-01
主題:	COPD Cigarette smoke Macrophage polarization Bexarotene PPARγ
オンライン･アクセス:	https://doi.org/10.1186/s12931-024-03064-x