Activation of PTHrP-cAMP-CREB1 signaling following p53 loss is essential for osteosarcoma initiation and maintenance

Mutations in the P53 pathway are a hallmark of human cancer. The identification of pathways upon which p53-deficient cells depend could reveal therapeutic targets that may spare normal cells with intact p53. In contrast to P53 point mutations in other cancer, complete loss of P53 is a frequent event...

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Bibliographic Details

Published in:	eLife
Main Authors:	Mannu K Walia, Patricia MW Ho, Scott Taylor, Alvin JM Ng, Ankita Gupte, Alistair M Chalk, Andrew CW Zannettino, T John Martin, Carl R Walkley
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2016-04-01
Subjects:	bone cancer osteoblast osteosarcoma
Online Access:	https://elifesciences.org/articles/13446