Pharmacological blockade of the mast cell MRGPRX2 receptor supports investigation of its relevance in skin disorders

IntroductionBecause MRGPRX2 is now recognized as the mast cell receptor for basic secretagogues, there is currently a tremendous interest in whether MRGRPX2 could play an important role in various pruritic dermatoses such as chronic spontaneous urticaria. Therefore, we sought to identify new potent...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Colin H. Macphee, Xinzhong Dong, Qi Peng, Daniel V. Paone, Per Stahl Skov, Katrine Baumann, Theresa Roethke, Deborah A. Goldspink, Samuel K. Pearson, Zining Wu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-10-01
Subjects:	mast cell MRGPRX2 skin neuropeptides substance P antagonist
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1433982/full