Pharmacological blockade of the mast cell MRGPRX2 receptor supports investigation of its relevance in skin disorders

IntroductionBecause MRGPRX2 is now recognized as the mast cell receptor for basic secretagogues, there is currently a tremendous interest in whether MRGRPX2 could play an important role in various pruritic dermatoses such as chronic spontaneous urticaria. Therefore, we sought to identify new potent...

書目詳細資料
發表在:	Frontiers in Immunology
Main Authors:	Colin H. Macphee, Xinzhong Dong, Qi Peng, Daniel V. Paone, Per Stahl Skov, Katrine Baumann, Theresa Roethke, Deborah A. Goldspink, Samuel K. Pearson, Zining Wu
格式:	Article
語言:	英语
出版:	Frontiers Media S.A. 2024-10-01
主題:	mast cell MRGPRX2 skin neuropeptides substance P antagonist
在線閱讀:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1433982/full

相似書籍

Therapeutic Potential of MRGPRX2 Inhibitors on Mast Cells
由: Hiroyuki Ogasawara, et al.
出版: (2021-10-01)

A Novel Cell Culture System to Improve MRGPRX2 Research in Human Skin Mast Cells
由: Zhuoran Li, et al.
出版: (2025-10-01)

Icatibant Acts as a Balanced Ligand of MRGPRX2 in Human Skin Mast Cells
由: Zhuoran Li, et al.
出版: (2025-08-01)

IL-33 and MRGPRX2-Triggered Activation of Human Skin Mast Cells—Elimination of Receptor Expression on Chronic Exposure, but Reinforced Degranulation on Acute Priming
由: Zhao Wang, et al.
出版: (2019-04-01)

Neuronal substance P-driven MRGPRX2-dependent mast cell degranulation products differentially promote vascular permeability
由: Masakazu Nagamine, et al.
出版: (2024-11-01)

CREB Is Critically Implicated in Skin Mast Cell Degranulation Elicited via FcεRI and MRGPRX2
由: Zhuoran Li, et al.
出版: (2024-10-01)

In the skin lesions of patients with mycosis fungoides, the number of MRGPRX2-expressing cells is increased and correlates with mast cell numbers
由: Man Hu, et al.
出版: (2023-10-01)

MRGPRX2 Activation by Rocuronium: Insights from Studies with Human Skin Mast Cells and Missense Variants
由: Chalatip Chompunud Na Ayudhya, et al.
出版: (2021-01-01)

Mutations of MRGPRX2, drug sensitivity, and genetic markers related to disease
由: Subashini Hemamala Ratnayake, MSc, BSc, et al.
出版: (2025-08-01)

Spatiotemporal Patterns of Substance P-Bound MRGPRX2 Reveal a Novel Connection Between Macropinosome Resolution and Secretory Granule Regeneration in Mast Cells
由: Pia Lazki-Hagenbach, et al.
出版: (2022-06-01)

Functional MRGPRX2 expression on peripheral blood-derived human mast cells increases at low seeding density and is suppressed by interleukin-9 and fetal bovine serum
由: Toon Ieven, et al.
出版: (2024-12-01)

Substance P analogs devoid of key residues fail to activate human mast cells via MRGPRX2
由: Shammy Raj, et al.
出版: (2023-05-01)

Thymic Stromal Lymphopoietin Promotes MRGPRX2-Triggered Degranulation of Skin Mast Cells in a STAT5-Dependent Manner with Further Support from JNK
由: Magda Babina, et al.
出版: (2021-01-01)

Quercetin Attenuates MRGPRX2-Mediated Mast Cell Degranulation via the MyD88/IKK/NF-κB and PI3K/AKT/ Rac1/Cdc42 Pathway
由: Zhao C, et al.
出版: (2024-10-01)

The development of murine bone marrow-derived mast cells expressing functional human MRGPRX2 for ex vivo and in vivo studies
由: Maram Bawazir, et al.
出版: (2024-12-01)

GRK2 inhibitors, paroxetine and CCG258747, attenuate IgE-mediated anaphylaxis but activate mast cells via MRGPRX2 and MRGPRB2
由: Monica Thapaliya, et al.
出版: (2022-10-01)

Authentic and Ectopically Expressed MRGPRX2 Elicit Similar Mechanisms to Stimulate Degranulation of Mast Cells
由: Pia Lazki-Hagenbach, et al.
出版: (2021-02-01)

Modulation of the Mas-Related G Protein-Coupled Receptor X2 (MRGPRX2) by Xenobiotic Compounds and Its Relevance to Human Diseases
由: Alicja Dziadowiec, et al.
出版: (2024-03-01)

MRGPRX2 signaling involves the Lysyl-tRNA synthetase and MITF pathway
由: Yanru Guo, et al.
出版: (2023-05-01)

Characterization of Mast Cells from Healthy and Varicose Human Saphenous Vein
由: Katrine T. Callesen, et al.
出版: (2022-05-01)

Inhibition of mast cell activation via MRGPRX2 receptor by Curcuma mangga and Sonchus arvensis water suspensions: An in vitro study
由: MUHAMMAD Sahid, et al.
出版: (2025-09-01)

N-demethylsinomenine metabolite and its prototype sinomenine activate mast cells via MRGPRX2 and aggravate anaphylaxis
由: Youfa Qin, et al.
出版: (2024-07-01)

MRGPRX2-Mediated Degranulation of Human Skin Mast Cells Requires the Operation of G<sub>αi</sub>, G<sub>αq</sub>, Ca++ Channels, ERK1/2 and PI3K—Interconnection between Early and Late Signaling
由: Zhao Wang, et al.
出版: (2022-03-01)

MRGPRX2 antagonist GE1111 attenuated DNFB-induced atopic dermatitis in mice by reducing inflammatory cytokines and restoring skin integrity
由: Trevor K. Wong, et al.
出版: (2024-05-01)

Functional human skin explants as tools for assessing mast cell activation and inhibition
由: Clarence Rachel Villanueva, et al.
出版: (2024-03-01)

The recent advances of mast cells in the pathogenesis of atopic dermatitis
由: Zhenzhen Xiao, et al.
出版: (2025-09-01)

Synergism between IL-33 and MRGPRX2/FcεRI Is Primarily Due to the Complementation of Signaling Modules, and Only Modestly Supplemented by Prolonged Activation of Selected Kinases
由: Kristin Franke, et al.
出版: (2023-11-01)

Functional heterogeneity of mast cells in cutaneous inflammation: implications for precision medicine
由: Surui A, et al.
出版: (2025-10-01)

Chronic urticaria and the pathogenic role of mast cells
由: Daniel Elieh-Ali-Komi, et al.
出版: (2023-07-01)

Small-Molecule Host-Defense Peptide Mimetic Antibacterial and Antifungal Agents Activate Human and Mouse Mast Cells via Mas-Related GPCRs
由: Ibrahim Alkanfari, et al.
出版: (2019-04-01)

Activation of ryanodine-sensitive calcium store drives pseudo-allergic dermatitis via Mas-related G protein-coupled receptor X2 in mast cells
由: Zhao Wang, et al.
出版: (2023-06-01)

Mast cell subsets and neuropeptides in leprosy reactions
由: Antunes Sérgio Luiz Gomes, et al.
出版: (2003-01-01)

Mast cell degranulation and bradykinin-induced angioedema - searching for the missing link
由: Grzegorz Porebski, et al.
出版: (2024-05-01)

“Relative symmetry with electronegativity of different key-groups” strategy for MRGPRX2 antagonist design and its effect on antigen-induced pulmonary inflammation
由: Jiayu Lu, et al.
出版: (2025-01-01)

The Underlying Rab Network of MRGPRX2-Stimulated Secretion Unveils the Impact of Receptor Trafficking on Secretory Granule Biogenesis and Secretion
由: Pia Lazki-Hagenbach, et al.
出版: (2024-01-01)

MrgX2 is a promiscuous receptor for basic peptides causing mast cell pseudo‐allergic and anaphylactoid reactions
由: Jak Grimes, et al.
出版: (2019-12-01)

GRK2 differentially regulates FcεRI and MRGPRB2-mediated responses in mast cells
由: Monica Thapaliya, et al.
出版: (2023-03-01)

Beyond Allergies—Updates on The Role of Mas-Related G-Protein-Coupled Receptor X2 in Chronic Urticaria and Atopic Dermatitis
由: Liron Lerner, et al.
出版: (2024-01-01)

An optimized method for IgE-mediated degranulation of human lung mast cells
由: Yitao Gong, et al.
出版: (2024-05-01)

Human Mast Cell Line HMC1 Expresses Functional Mas-Related G-Protein Coupled Receptor 2
由: Maud A. W. Hermans, et al.
出版: (2021-03-01)