A molecular perspective on mGluR5 regulation in the antidepressant effect of ketamine

Ketamine, a non-competitive N-methyl-D-aspartate receptor (NMDAR) antagonist, has received much attention for its rapid antidepressant effects. A single administration of ketamine elicits rapid and sustained antidepressant effects in both humans and animals. Current efforts are focused on uncovering...

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Bibliographic Details

Published in:	Pharmacological Research
Main Authors:	Ola Sobhy A. Elmeseiny, Heidi Kaastrup Müller
Format:	Article
Language:	English
Published:	Elsevier 2024-02-01
Subjects:	mGluR5 Ketamine Homer1a Antidepressant Molecular mechanism
Online Access:	http://www.sciencedirect.com/science/article/pii/S1043661824000252