The kringle IV type 2 domain variant 4925G>A causes the elusive association signal of the LPA pentanucleotide repeat

Lipoprotein(a) [Lp(a)] concentrations are regulated by the LPA gene mainly via the large kringle IV-type 2 (KIV-2) copy number variation and multiple causal variants. Early studies suggested an effect of long pentanucleotide repeat (PNR) alleles (10 and 11 repeats, PNR10 and PNR11) in the LPA promot...

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Bibliographic Details

Published in:	Journal of Lipid Research
Main Authors:	Rebecca Grüneis, Hansi Weissensteiner, Claudia Lamina, Sebastian Schönherr, Lukas Forer, Silvia Di Maio, Gertraud Streiter, Annette Peters, Christian Gieger, Florian Kronenberg, Stefan Coassin
Format:	Article
Language:	English
Published:	Elsevier 2022-12-01
Subjects:	lipoprotein(a) lipoprotein(a) metabolism apolipoproteins genomics lipoproteins apolipoprotein(a)
Online Access:	http://www.sciencedirect.com/science/article/pii/S0022227522001390