A phase 1 trial of the safety, tolerability and biological effects of intravenous Enadenotucirev, a novel oncolytic virus, in combination with chemoradiotherapy in locally advanced rectal cancer (CEDAR)

Abstract Background Chemoradiotherapy remains the standard of care for locally advanced rectal cancer. Efforts to intensify treatment and increase response rates have yet to yield practice changing results due to increased toxicity and/or absence of increased radiosensitization. Enadenotucirev (EnAd...

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Bibliographic Details

Published in:	Radiation Oncology
Main Authors:	Séan M. O’Cathail, Steven Davis, Jane Holmes, Richard Brown, Kerry Fisher, Leonard Seymour, Richard Adams, James Good, David Sebag-Montefiore, Tim Maughan, Maria A. Hawkins
Format:	Article
Language:	English
Published:	BMC 2020-06-01
Subjects:	Radiation Phase I Rectal Cancer Oncolytic virus Immuno-oncology
Online Access:	http://link.springer.com/article/10.1186/s13014-020-01593-5