Local heterogeneity of normal lung parenchyma and small airways disease are associated with COPD severity and progression

Abstract Background Small airways disease (SAD) is a major cause of airflow obstruction in COPD patients and has been identified as a precursor to emphysema. Although the amount of SAD in the lungs can be quantified using our Parametric Response Mapping (PRM) approach, the full breadth of this reado...

Full description

Bibliographic Details

Published in:	Respiratory Research
Main Authors:	Alexander J. Bell, Ravi Pal, Wassim W. Labaki, Benjamin A. Hoff, Jennifer M. Wang, Susan Murray, Ella A. Kazerooni, Stefanie Galban, David A. Lynch, Stephen M. Humphries, Fernando J. Martinez, Charles R. Hatt, MeiLan K. Han, Sundaresh Ram, Craig J. Galban
Format:	Article
Language:	English
Published:	BMC 2024-02-01
Subjects:	Chronic obstructive pulmonary disease Small airways disease Parametric response mapping Computed tomography of the chest Machine learning Emphysema
Online Access:	https://doi.org/10.1186/s12931-024-02729-x