A membrane-associated phosphoswitch in Rad controls adrenergic regulation of cardiac calcium channels

The ability to fight or flee from a threat relies on an acute adrenergic surge that augments cardiac output, which is dependent on increased cardiac contractility and heart rate. This cardiac response depends on β-adrenergic–initiated reversal of the small RGK G protein Rad–mediated inhibition of vo...

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Bibliographic Details

Published in:	The Journal of Clinical Investigation
Main Authors:	Arianne Papa, Pedro J. del Rivero Morfin, Bi-Xing Chen, Lin Yang, Alexander N. Katchman, Sergey I. Zakharov, Guoxia Liu, Michael S. Bohnen, Vivian Zheng, Moshe Katz, Suraj Subramaniam, Joel A. Hirsch, Sharon Weiss, Nathan Dascal, Arthur Karlin, Geoffrey S. Pitt, Henry M. Colecraft, Manu Ben-Johny, Steven O. Marx
Format:	Article
Language:	English
Published:	American Society for Clinical Investigation 2024-03-01
Subjects:	Cardiology
Online Access:	https://doi.org/10.1172/JCI176943