A novel synthetic oleanane triterpenoid, 2‐cyano‐3,12‐dioxoolean‐1,9‐dien‐28‐oic acid, regulates mechanical allodynia by rescuing neuronal cell death and glial cell activation in the spinal cord of resiniferatoxin‐treated rats

Abstract Background Treating postherpetic neuralgia (PHN), which is characterized with a long‐lasting lancinating mechanical allodynia or hyperalgesia, is a big challenge as it is hard to achieve complete resolution. A synthetic triterpenoid, CDDO (2‐cyano‐3,12‐dioxoolean‐1,9‐dien‐28‐oic acid) can e...

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Bibliographic Details

Published in:	Brain and Behavior
Main Authors:	Ying‐Yi Lu, Chia‐Yang Lin, Hung‐Pei Tsai, Chih‐Lung Lin, Chieh‐Hsin Wu
Format:	Article
Language:	English
Published:	Wiley 2024-02-01
Subjects:	2‐cyano‐3,12‐dioxoolean‐1,9‐dien‐28‐oic acid mechanical allodynia resiniferatoxin triterpenoid
Online Access:	https://doi.org/10.1002/brb3.3398