Fads2 knockout mice reveal that ALA prevention of hepatic steatosis is dependent on delta-6 desaturase activity

The production of the omega-3 long-chain polyunsaturated fatty acids (n-3 LCPUFA) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) from alpha-linolenic acid (ALA) relies on the delta-6 desaturase (D6D) enzyme encoded by the Fads2 gene. While EPA and DHA reduce hepatic triacylglycerol (TAG)...

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Bibliographic Details

Published in:	Journal of Lipid Research
Main Authors:	Blair MacLeod, Chenxuan Wang, Liam H. Brown, Emma Borkowski, Manabu T. Nakamura, Kyle RD. Wells, Keith R. Brunt, Ewa Harasim-Symbor, Adrian Chabowski, David M. Mutch
Format:	Article
Language:	English
Published:	Elsevier 2024-10-01
Subjects:	delta-6 desaturase gene expression glyceroneogenesis Fads2 fish oil lipogenesis
Online Access:	http://www.sciencedirect.com/science/article/pii/S0022227524001470