A Novel Glycoproteomics Workflow Reveals Dynamic O-GlcNAcylation of COPγ1 as a Candidate Regulator of Protein Trafficking

O-linked β-N-acetylglucosamine (O-GlcNAc) is an abundant and essential intracellular form of protein glycosylation in animals and plants. In humans, dysregulation of O-GlcNAcylation occurs in a wide range of diseases, including cancer, diabetes, and neurodegeneration. Since its discovery more than 3...

Full description

Bibliographic Details

Published in:	Frontiers in Endocrinology
Main Authors:	Nathan J. Cox, Peter M. Luo, Timothy J. Smith, Brittany J. Bisnett, Erik J. Soderblom, Michael Boyce
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2018-10-01
Subjects:	O-GlcNAc glycoproteomics SILAC click chemistry COPI vesicle trafficking protein secretion
Online Access:	https://www.frontiersin.org/article/10.3389/fendo.2018.00606/full