Neural growth patterns: how random and aligned fibers guide 3D cell organization and pseudospheroid formation

Background and purposeElectrospun biomaterials replicate the structural complexity of the extracellular matrix (ECM), providing mechanical support and promoting neural cell survival and organization. Fiber orientation is a key determinant of neural cell behavior, influencing adhesion, migration, and...

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Bibliographic Details

Published in:	Frontiers in Bioengineering and Biotechnology
Main Authors:	Jana Hlinkova, Karolina Dziemidowicz, Mathilde M. Ullrich, Anne Eriksson Agger, Aina-Mari Lian, Janne Elin Reseland, Athina Samara
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-10-01
Subjects:	PCL fibers neuroblastoma cells SH-SY5Y aligned random
Online Access:	https://www.frontiersin.org/articles/10.3389/fbioe.2025.1659965/full