High fructose rewires gut glucose sensing via glucagon-like peptide 2 to impair metabolic regulation in mice

Objective: Increased fructose consumption contributes to type 2 diabetes (T2D) and metabolic dysfunction-associated steatotic liver disease (MASLD), but the mechanisms are ill-defined. Gut nutrient sensing involves enterohormones like Glucagon-like peptide (Glp)2, which regulates the absorptive capa...

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Bibliographic Details

Published in:	Molecular Metabolism
Main Authors:	Eya Sellami, Paulo Henrique Evangelista-Silva, Caio Jordão Teixeira, Khoudia Diop, Patricia Mitchell, Fernando Forato Anhê
Format:	Article
Language:	English
Published:	Elsevier 2025-03-01
Subjects:	Glucagon-like peptide 2 Glucagon-like peptide 2 receptor Type 2 diabetes Obesity Sugar
Online Access:	http://www.sciencedirect.com/science/article/pii/S2212877825000080