Reduced tissue osmolarity increases TRPV4 expression and pro-inflammatory cytokines in intervertebral disc cells

The mechanical behaviour and cellular metabolism of intervertebral discs (IVDs) and articular cartilage are strongly influenced by their proteoglycan content and associated osmotic properties. This osmotic environment is a biophysical signal that changes with disease and may contribute to the elevat...

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Bibliographic Details

Published in:	European Cells & Materials
Main Authors:	BA Walter, D Purmessur, A Moon, J Occhiogrosso, DM Laudier, AC Hecht, JC Iatridis
Format:	Article
Language:	English
Published:	Forum Multimedia Publishing LLC 2016-07-01
Subjects:	TRPV4 intervertebral disc osmolarity degeneration mechanobiology
Online Access:	http://www.ecmjournal.org/papers/vol032/pdf/v032a08.pdf