Quantitation of polysorbate 80 in recombinant protein formulation using high-performance liquid chromatography

Objectives. Polysorbate 80 (PS80) quantification in biopharmaceutical products has always been challenging owing to its minute content, absorption to the protein backbone, lack of specific chromophoric PS80 groups, and heterogenic nature. This work is aimed at developing an express method for PS80 a...

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التفاصيل البيبلوغرافية

الحاوية / القاعدة:	Тонкие химические технологии
المؤلفون الرئيسيون:	A. D. Askretkov, D. O. Shatalov, N. V. Orlova, D. I. Zybin, V. V. Nikolaeva, A. A. Klishin, E. S. Tuzova, D. S. Minenkov, S. A. Kedik, Yu. A. Seregin
التنسيق:	مقال
اللغة:	الروسية
منشور في:	MIREA - Russian Technological University 2022-04-01
الموضوعات:	polysorbate 80 hydrolysis hplc oleic acid therapeutic proteins spectrophotometric detection
الوصول للمادة أونلاين:	https://www.finechem-mirea.ru/jour/article/view/1798