Semaphorin 7a aggravates TGF-β1-induced airway EMT through the FAK/ERK1/2 signaling pathway in asthma

BackgroundTGF-β1 can induce epithelial-mesenchymal transition (EMT) in primary airway epithelial cells (AECs). Semaphorin7A (Sema7a) plays a crucial role in regulating immune responses and initiating and maintaining transforming growth factor β1 TGF-β1-induced fibrosis.ObjectiveTo determine the expr...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Haiying Peng, Fei Sun, Yunxiu Jiang, Zihan Guo, Xinyi Liu, Anli Zuo, Degan Lu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-11-01
Subjects:	asthma semaphorin 7A airway remodeling epithelial-mesenchymal transition TGF-β1
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1167605/full