USP4-Mediated deubiquitination of A2AR suppresses autophagy-dependent ferroptosis in gastric cancer

Abstract Deubiquitinating enzymes (DUBs) are crucial for regulating the degradation of specific proteins and represent a novel therapeutic direction in cancer. In gastric cancer, USP4 levels are significantly elevated, though its therapeutic potential remains underexplored. Our study demonstrates th...

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Bibliographic Details

Published in:	Cellular and Molecular Life Sciences
Main Authors:	Xuan Zhao, Sheng Lu, Zhaoyu Xiang, Min Yan, Zheng-Gang Zhu, Feng Dong, Chao Yan
Format:	Article
Language:	English
Published:	Springer 2025-10-01
Subjects:	Autophagy Ferroptosis Gastric Cancer Deubiquitination
Online Access:	https://doi.org/10.1007/s00018-025-05826-2