Histone lysine methyltransferases MLL3 and MLL4 direct gene expression to produce platelets efficiently

Abstract Circulating blood platelets are responsible for maintaining hemostasis. They are released into blood vessels from mature megakaryocytes. Although several transcription factors have been reported to orchestrate the transcriptional programs required for platelet production, how chromatin regu...

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Bibliographic Details

Published in:	Nature Communications
Main Authors:	Guozhen Gao, Josimar Dornelas Moreira, Prosun Das, Kevin Lin, Kai Ge, Taiping Chen, Yue Lu, Margarida A. Santos
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-07-01
Online Access:	https://doi.org/10.1038/s41467-025-61247-6