Aptamers with Self-Loading Drug Payload and pH-Controlled Drug Release for Targeted Chemotherapy

Doxorubicin (DOX) is a common anti-tumor drug that binds to DNA or RNA via non-covalent intercalation between G-C sequences. As a therapeutic agent, DOX has been used to form aptamer–drug conjugates for targeted cancer therapy in vitro and in vivo. To improve the therapeutic potential of aptamer–DOX...

Full description

Bibliographic Details

Published in:	Pharmaceutics
Main Authors:	Zihua Zeng, Jianjun Qi, Quanyuan Wan, Youli Zu
Format:	Article
Language:	English
Published:	MDPI AG 2021-08-01
Subjects:	aptamer–drug conjugate doxorubicin high drug payload self-loading targeted chemotherapy
Online Access:	https://www.mdpi.com/1999-4923/13/8/1221