Loss of Y in regulatory T lymphocytes in the tumor micro-environment of primary colorectal cancers and liver metastases

Abstract Male sex is a risk factor for colorectal cancer (CRC) with higher illness burden and earlier onset. Thus, we hypothesized that loss of chromosome Y (LOY) in the tumor micro-environment (TME) might be involved in oncogenesis. Previous studies show that LOY in circulating leukocytes of aging...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Magdalena Wójcik, Ulana Juhas, Elyas Mohammadi, Jonas Mattisson, Kinga Drężek-Chyła, Edyta Rychlicka-Buniowska, Bożena Bruhn-Olszewska, Hanna Davies, Katarzyna Chojnowska, Paweł Olszewski, Michał Bieńkowski, Michał Jankowski, Olga Rostkowska, Andrzej Hellmann, Rafał Pęksa, Jacek Kowalski, Marek Zdrenka, Jarek Kobiela, Wojciech Zegarski, Wojciech Biernat, Łukasz Szylberg, Piotr Remiszewski, Jakub Mieczkowski, Natalia Filipowicz, Jan P. Dumanski
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-04-01
Online Access:	https://doi.org/10.1038/s41598-024-60049-y