Cyclophostin and Cyclipostins analogues counteract macrolide-induced resistance mediated by erm(41) in Mycobacterium abscessus

Abstract Background Mycobacterium abscessus is an emerging pathogen causing severe pulmonary infections, particularly in individuals with underlying conditions, such as cystic fibrosis or chronic obstructive pulmonary disease. Macrolides, such as clarithromycin (CLR) or azithromycin (AZM), represent...

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Bibliographic Details
Published in:Journal of Biomedical Science
Main Authors: Morgane Sarrazin, Isabelle Poncin, Patrick Fourquet, Stéphane Audebert, Luc Camoin, Yann Denis, Pierre Santucci, Christopher D. Spilling, Laurent Kremer, Vincent Le Moigne, Jean-Louis Herrmann, Jean-François Cavalier, Stéphane Canaan
Format: Article
Language:English
Published: BMC 2024-12-01
Subjects:
Mycobacterium abscessus
Drug susceptibility
Macrolide
Resistance
Synergy testing
Erm(41)
Online Access:https://doi.org/10.1186/s12929-024-01091-w

Internet

https://doi.org/10.1186/s12929-024-01091-w

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