Involvement of ERK-Nrf-2 signaling in ionizing radiation induced cell death in normal and tumor cells.

Prolonged oxidative stress favors tumorigenic environment and inflammation. Oxidative stress may trigger redox adaptation mechanism(s) in tumor cells but not normal cells. This may increase levels of intracellular antioxidants and establish a new redox homeostasis. Nrf-2, a master regulator of batte...

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Bibliographic Details

Published in:	PLoS ONE
Main Authors:	Raghavendra S Patwardhan, Rahul Checker, Deepak Sharma, Santosh K Sandur, Krishna B Sainis
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2013-01-01
Online Access:	http://europepmc.org/articles/PMC3679038?pdf=render