The Initiation, but Not the Persistence, of Experimental Spondyloarthritis Is Dependent on Interleukin-23 Signaling

IL-17A is a central driver of spondyloarthritis (SpA), its production was originally proposed to be IL-23 dependent. Emerging preclinical and clinical evidence suggests, however, that IL-17A and IL-23 have a partially overlapping but distinct biology. We aimed to assess the extent to which IL-17A-dr...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Melissa N. van Tok, Songqing Na, Christopher R. Lao, Marina Alvi, Desirée Pots, Marleen G. H. van de Sande, Joel D. Taurog, Jonathon D. Sedgwick, Dominique L. Baeten, Leonie M. van Duivenvoorde
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2018-07-01
Subjects:	spondyloarthritis animal models HLA-B27 tg rats IL-23R IL-23 signaling IL-17A
Online Access:	https://www.frontiersin.org/article/10.3389/fimmu.2018.01550/full