Structural snapshots of Mycobacterium tuberculosis enolase reveal dual mode of 2PG binding and its implication in enzyme catalysis

Enolase, a ubiquitous enzyme, catalyzes the reversible conversion of 2-phosphoglycerate (2PG) to phosphoenolpyruvate (PEP) in the glycolytic pathway of organisms of all three domains of life. The underlying mechanism of the 2PG to PEP conversion has been studied in great detail in previous work, how...

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Bibliographic Details

Published in:	IUCrJ
Main Authors:	Mohammed Ahmad, Bhavya Jha, Sucharita Bose, Satish Tiwari, Abhisek Dwivedy, Deepshikha Kar, Ravikant Pal, Richard Mariadasse, Tanya Parish, Jeyaraman Jeyakanthan, Kutti R. Vinothkumar, Bichitra Kumar Biswal
Format:	Article
Language:	English
Published:	International Union of Crystallography 2023-11-01
Subjects:	mycobacterium tuberculosis enolase gluconeogenesis cryo-electron microscopy x-ray crystallography enzyme mechanisms
Online Access:	http://scripts.iucr.org/cgi-bin/paper?S2052252523008485