Gossypetin targets the liver-brain axis to alleviate pre-existing liver fibrosis and hippocampal neuroinflammation in mice

Liver fibrosis occurs in response to chronic damage and inflammation to the liver. Leaving untreated, it can lead to decreased liver function and can eventually progress to cirrhosis, a more advanced and irreversible state of liver damage. Clinical investigations showed that chronic liver disease as...

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Bibliographic Details

Published in:	Frontiers in Pharmacology
Main Authors:	Cenlu Xu, Haoran Tai, Yanan Chu, Ye Liu, Jiacheng He, Yiran Wang, Bingyin Su, Shurong Li
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-05-01
Subjects:	liver fibrosis p38 MAPK gossypetin hippocampus neuroinflammation
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2024.1385330/full