Identification of a GABAergic neural circuit governing leptin signaling deficiency-induced obesity

The hormone leptin is known to robustly suppress food intake by acting upon the leptin receptor (LepR) signaling system residing within the agouti-related protein (AgRP) neurons of the hypothalamus. However, clinical studies indicate that leptin is undesirable as a therapeutic regiment for obesity,...

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Bibliographic Details

Published in:	eLife
Main Authors:	Yong Han, Yang He, Lauren Harris, Yong Xu, Qi Wu
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2023-04-01
Subjects:	leptin obesity glucose GABA Agrp leptin receptor
Online Access:	https://elifesciences.org/articles/82649