An in situ and in vitro investigation of cytoplasmic TDP-43 inclusions reveals the absence of a clear amyloid signature

AbstractIntroduction: Several neurodegenerative conditions are associated with a common histopathology within neurons of the central nervous system, consisting of the deposition of cytoplasmic inclusions of TAR DNA-binding protein 43 (TDP-43). Such inclusions have variably been described as morpholo...

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Bibliographic Details

Published in:	Annals of Medicine
Main Authors:	Roberta Cascella, Martina Banchelli, Seyyed Abolghasem Ghadami, Diletta Ami, Maria Cristina Gagliani, Alessandra Bigi, Tommaso Staderini, Davide Tampellini, Katia Cortese, Cristina Cecchi, Antonino Natalello, Hadi Adibi, Paolo Matteini, Fabrizio Chiti
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2023-12-01
Subjects:	Motor neuron disease MND Lou Gehrig’s disease amyotrophic lateral sclerosis frontotemporal lobar degeneration ALS
Online Access:	https://www.tandfonline.com/doi/10.1080/07853890.2022.2148734