Hereditary Transthyretin Amyloidosis (hATTR) with Polyneuropathy Clusters Are Located in Ancient Mining Districts: A Possible Geochemical Origin of the Disease

Hereditary transthyretin amyloidosis (hATTR) with polyneuropathy (formerly known as Familial Amyloid Polyneuropathy (FAP)) is an endemic amyloidosis involving the harmful aggregation of proteins, most commonly transthyretin (TTR) but sometimes also apolipoprotein A-1 or gelsolin. hATTR appears to be...

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Bibliographic Details

Published in:	Biomolecules
Main Authors:	Per M. Roos, Sebastian K. T. S. Wärmländer
Format:	Article
Language:	English
Published:	MDPI AG 2024-06-01
Subjects:	neurodegeneration protein aggregation proteinopathy metal–protein binding metal toxicity Familial Amyloid Polyneuropathy (FAP)
Online Access:	https://www.mdpi.com/2218-273X/14/6/652