Rationale for Therapeutic Silencing of Alpha-Synuclein in Parkinson’s Disease

The purpose of this paper is to provide the rationale for therapeutic silencing of the alpha-synuclein gene (SNCA) in Parkinson’s disease (PD). The paper reviews the public health significance of PD; the causal links between rare SNCA variants and familial PD; the association of common SNCA variants...

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Bibliographic Details
Published in:Journal of Movement Disorders
Main Author: Demetrius M. Maraganore
Format: Article
Language:English
Published: Korean Movement Disorder Society 2011-05-01
Subjects:
Online Access:http://e-jmd.org/upload/jmd-4-1-1-1.pdf