Probable human origin of the SARS-CoV-2 polybasic furin cleavage motif

Abstract Background The key evolutionary step leading to the pandemic virus was the acquisition of the PRRA furin cleavage motif at the spike glycoprotein S1/S2 junction by a progenitor of SARS-CoV-2. Two of its features draw attention: (i) it is absent in other known lineage B beta-coronaviruses, i...

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Bibliographic Details

Published in:	BMC Genomic Data
Main Author:	Antonio R. Romeu
Format:	Article
Language:	English
Published:	BMC 2023-11-01
Subjects:	SARS-CoV-2 Polybasic furin cleavage motif Human mRNA transcripts Spike glycoprotein insertions Bioinformatics
Online Access:	https://doi.org/10.1186/s12863-023-01169-8