GEF-H1 Transduces FcεRI Signaling in Mast Cells to Activate RhoA and Focal Adhesion Formation during Exocytosis

When antigen-stimulated, mast cells release preformed inflammatory mediators stored in cytoplasmic granules. This occurs via a robust exocytosis mechanism termed degranulation. Our previous studies revealed that RhoA and Rac1 are activated during mast cell antigen stimulation and are required for me...

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Bibliographic Details

Published in:	Cells
Main Authors:	Yitian Guo, Judeah Negre, Gary Eitzen
Format:	Article
Language:	English
Published:	MDPI AG 2023-02-01
Subjects:	Rho GTPase guanine nucleotide exchange factor GEF-H1 ARHGEF2 RhoA mast cell
Online Access:	https://www.mdpi.com/2073-4409/12/4/537