Lyve-1 deficiency enhances the hepatic immune microenvironment entailing altered susceptibility to melanoma liver metastasis

Abstract Background Hyaluronan receptor LYVE-1 is expressed by liver sinusoidal endothelial cells (LSEC), lymphatic endothelial cells and specialized macrophages. Besides binding to hyaluronan, LYVE-1 can mediate adhesion of leukocytes and cancer cells to endothelial cells. Here, we assessed the imp...

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Bibliographic Details

Published in:	Cancer Cell International
Main Authors:	Anna Sophia Jauch, Sebastian A. Wohlfeil, Céline Weller, Bianca Dietsch, Verena Häfele, Ana Stojanovic, Maximilian Kittel, Hendrik Nolte, Adelheid Cerwenka, Michael Neumaier, Kai Schledzewski, Carsten Sticht, Philipp-Sebastian Reiners-Koch, Sergij Goerdt, Cyrill Géraud
Format:	Article
Language:	English
Published:	BMC 2022-12-01
Subjects:	Lyve-1 Liver Immune microenvironment Liver homeostasis Liver metastasis
Online Access:	https://doi.org/10.1186/s12935-022-02800-x