A paracrine activin A–mDia2 axis promotes squamous carcinogenesis via fibroblast reprogramming

Abstract Cancer‐associated fibroblasts (CAFs) are key regulators of tumorigenesis and promising targets for next‐generation therapies. We discovered that cancer cell‐derived activin A reprograms fibroblasts into pro‐tumorigenic CAFs. Mechanistically, this occurs via Smad2‐mediated transcriptional re...

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Bibliographic Details

Published in:	EMBO Molecular Medicine
Main Authors:	Michael Cangkrama, Mateusz Wietecha, Nicolas Mathis, Rin Okumura, Luca Ferrarese, Dunja Al‐Nuaimi, Maria Antsiferova, Reinhard Dummer, Metello Innocenti, Sabine Werner
Format:	Article
Language:	English
Published:	Springer Nature 2020-03-01
Subjects:	activin CAF carcinogenesis mDia2 tumor microenvironment
Online Access:	https://doi.org/10.15252/emmm.201911466