The Ins and Outs of a Polyglutamine Neurodegenerative Disease: Spinocerebellar Ataxia Type 1 (SCA1)
Polyglutamine neurodegenerative disorders are characterized by the expansion of a glutamine tract within the mutant disease-causing protein. Expression of the mutant protein induces a progressive loss of neuronal function and the subsequent neurodegeneration of a set of neurons characteristic to eac...
| Published in: | Neurobiology of Disease |
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| Main Author: | |
| Format: | Article |
| Language: | English |
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Elsevier
2000-06-01
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S096999610090305X |