CPSF6 defines a conserved capsid interface that modulates HIV-1 replication.

The HIV-1 genome enters cells inside a shell comprised of capsid (CA) protein. Variation in CA sequence alters HIV-1 infectivity and escape from host restriction factors. However, apart from the Cyclophilin A-binding loop, CA has no known interfaces with which to interact with cellular cofactors. He...

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Bibliographic Details

Published in:	PLoS Pathogens
Main Authors:	Amanda J Price, Adam J Fletcher, Torsten Schaller, Tom Elliott, KyeongEun Lee, Vineet N KewalRamani, Jason W Chin, Greg J Towers, Leo C James
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2012-01-01
Online Access:	https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1002896&type=printable