PerfuPul—A Versatile Perfusable Platform to Assess Permeability and Barrier Function of Air Exposed Pulmonary Epithelia

Complex in vitro models, especially those based on human cells and tissues, may successfully reduce or even replace animal models within pre-clinical development of orally inhaled drug products. Microfluidic lung-on-chips are regarded as especially promising models since they allow the culture of lu...

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Bibliographic Details

Published in:	Frontiers in Bioengineering and Biotechnology
Main Authors:	Patrick Carius, Aurélie Dubois, Morvarid Ajdarirad, Arbel Artzy-Schnirman, Josué Sznitman, Nicole Schneider-Daum, Claus-Michael Lehr
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-10-01
Subjects:	air-liquid interface (ALI) permeability perfusion transepithelial electrical resistance (TEER) aerosol deposition drug testing
Online Access:	https://www.frontiersin.org/articles/10.3389/fbioe.2021.743236/full